The 147th WPI-IIIS seminar

EVENTS

Date	April 10, 2019
Time	12:00 -13:00
Venue	1F Auditorium, IIIS Building, University of Tsukuba
Access	Take a bus bound for "Tsukuba Daigaku Chuo" or the "University Loop-line On-campus Bus [Tsukuba Daigaku Junkan Bus]" and get off at Oikoshi Gakusei Shukusha Mae
Speaker	Dr. Takayasu Mikuni, Brain Research Institute, Niigata University
Subject	"Genome Editing in Mammalian Brain in vivo: Key Technologies and Future Applications"
Summary	Rapid and precise genome editing using CRISPR-Cas systems is a powerful technology in various scientific fields. Especially, genome editing through homology-directed repair (HDR) provides a versatile approach to precisely introduce insertions, deletions or replacements in the genome. However, it has been considered to be difficult to induce HDR in postmitotic neurons, limiting the application of precise genome editing in the field of neuroscience. Here Dr. Mikuni presents two strategies, SLENDR and vSLENDR, to induce HDR- mediated genome editing in mammalian brain in vivo (Cell 2016, Neuron 2017). Rapid and precise genome editing in the brain will allow for a wide range of applications in neuroscience research, such as high-throughput monitoring and manipulation of endogenous gene products in brain tissue. Click here for more information: http://wpi-iiis.tsukuba.ac.jp/seminar
Contact	International Institute for Integrative Sleep Medicine Phone: 029-853-8080 (ext.8080)